The treatment of severe depression remains a forbidding scientific frontier (Nemeroff, 2007). No current pharmacological therapy seems more than occasionally effective on those who suffer from it. Of the traditional device-based treatments, only Electro-Convulsive Therapy (ECT) has shown itself effective, and ECT is only effective to some extent and in some cases. ECT also comes with a significant price tag and consistent mid-level side effects. Many patients do not respond to any therapy, while the suicide rate among victims of severe depression remains tragically high.
Treatment-resistant depression, whether moderate or severe, is an unusually expensive disorder because it tends to affect people at relatively young ages, making them less able to perform at work, frequently absent from work, or simply unable to work at all for decades on end (Crown, 2002). Researchers are currently investigating various novel approaches to the treatment of severe depression. But expanding the range of possible approaches to such a refractory syndrome can in the long run lead to a more optimal outcome. Here are three new approaches not currently under consideration.