Caffeine, the world’s most widely used psychoactive substance, attracts a lot of research. Caffeine also attracts controversy. Some scientists argue that caffeine is a benign and useful drug whose side effects are only of concern in regard to a small number of “sensitives”, including those with pre-existing anxiety or similar symptoms. They note that caffeine improves attention, reaction time, numeric and verbal memory, and work output and endurance in long-term exercise.

But other researchers claim that caffeine causes multiple damaging effects ranging from boosting blood pressure to disrupting sleep, and that these affect hundreds of millions.

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